The side effects of semaglutide, particularly the gastrointestinal ones, occur directly because of how the drug works
GLP-1 receptors exist in the area postrema of the brainstem, the region that controls the vomit reflex
Obviously, we are embracing the medications and some of the benefits of using a kind of a multifaceted, interdisciplinary approach, but yet the, the the discontinuation trends, sort of continue
IUBMB Life 75(10):856867 Mllerhj MB, Veidal SS, Thrane KT, Or D, Overgaard A, Salinas CG, Madsen MR, Pfisterer L, Vyberg M, Simon E, Broermann A, Vrang N, Jelsing J, Feigh M, Hansen HH (2022) Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH
This gives both consumers and manufacturers more confidence
Semaglutide & Tirzepatide is most effective when combined with healthy lifestyle changes, including diet and exercise